If you want to listen to the absolute best of The Beatles, iTunes is possibly the best place to go. Pretty soon, the already extensive collection will get even larger with the release of some material in digital form for the very first time. Live at the BBC Volume 1 and Volume 2 will be available to download from mid-November at $19.99 a piece.
Between March 1962 and June 1965, The Beatles became a familiar presence on BBC airwaves, performing more than 80 songs during dozens of appearances on national radio. The first compilation of these sessions, Live at the BBC – originally issued in 1994, but now available digitally for the first time – is joined by a previously unreleased second volume of music from this exhilarating period in the band's history.
iTunes famously finally got The Beatles' collection into the store back in 2010, and is something yet to be matched by digital music competitors. It's also not the first batch of BBC content to hit the store in recent weeks, with some previously lost episodes of Doctor Who being remastered and released to iTunes.
Pre-order the new releases at the links below. Any Beatles fans out there pulling the trigger?
LOS ANGELES (AP) — Apparently astronauts are no match for Jackass.
Paramount's "Jackass Presents: Bad Grandpa" topped the weekend box office with $32 million, according to studio estimates Sunday, sinking three-week champ "Gravity" to second place.
"Bad Grandpa" stars Johnny Knoxville as an accident-prone grandfather in the hidden-camera comedy.
"It's been a very heavy fall in terms of the content of the movies, so I think audiences were ready for something completely lighthearted and out of leftfield," said box-office analyst Paul Dergarabedian of Rentrak.
"Gravity," which stars Sandra Bullock and George Clooney as astronauts on a troubled spacecraft, has soared since its debut three weeks ago. The Warner Bros. space adventure added another $20.3 million to its haul over the weekend, bringing its domestic ticket totals to nearly $200 million.
Paramount's president of domestic distribution said it's gratifying to see "Jackass" unseat the space adventure from its top spot.
"We weren't competing with 'Gravity,'" said Don Harris. "We were not competitive in any other way than who was going to be No. 1 this weekend."
Sony's high-seas thriller "Captain Phillips," starring Tom Hanks, held on to third place with $11.8 million.
An all-star cast including Brad Pitt, Cameron Diaz, Penelope Cruz and Michael Fassbender wasn't enough to draw audiences to "The Counselor," which opened in fourth place. The gritty Fox drama is a "very challenging, provocative film," according to Chris Aronson, who heads distribution for Fox.
"We're fine," he said. "I know we have a very competitive environment."
He expects the film, written by Cormac McCarthy, to find its audience as it rolls out internationally in the coming weeks.
Another drama, Fox Searchlight's "12 Years a Slave," edged into the top 10 despite playing in only 123 theaters.
"This portends a tremendous expansion trajectory for the film" directed by Steve McQueen and starring Chiwetel Eijofor, Dergarabedian said. "In a sea of films that are in over 1,000 theaters, '12 Years a Slave' is distinguishing itself by doing so well."
The overall box office is up 9 percent over the same weekend last year, Dergarabedian said.
"Fall is probably the best season to be a moviegoer," he said. "You can get really highbrow films, Oscar contenders, but you can also get something like 'Bad Grandpa,' which satisfies the needs for audiences to just have fun and check their brain at the door."
Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Rentrak. Where available, latest international numbers for Friday through Sunday are also included. Final domestic figures will be released Monday.
1. "Jackass Presents: Bad Grandpa," $32 million ($8.1 million international).
2. "Gravity," $20.3 million ($36.6 million international).
3. "Captain Phillips," $11.8 million ($12.1 million international).
4. "The Counselor," $8 million.
5. "Cloudy with a Chance of Meatballs 2," $6.1 million ($17.9 million international).
6. "Carrie," $5.9 million.
7. "Escape Plan," $4.3 million ($7 million international).
8. "12 Years a Slave," $2.15 million.
9. "Enough Said," $1.55 million.
10. "Prisoners," $1.06 million ($5.1 million international).
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Estimated weekend ticket sales Friday through Sunday at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:
1. "Gravity," $36.6 million.
2. "Cloudy with a Chance of Meatballs 2," $17.9 million.
3. "Turbo," $14.2 million.
4. "Captain Phillips," $12.1 million.
5. "Jackass Presents: Bad Grandpa," $8.1 million.
6. "Escape Plan," $7 million.
7. "The Wolverine," $6.7 million.
8. "Insidious Chapter 2," $6.5 million.
9. "Now You See Me," $5.6 million.
10. "Prisoners," $5.1 million.
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Follow AP Entertainment Writer Sandy Cohen at www.twitter.com/APSandy .
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Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.
Women gather on the steps of an apartment building opposite the scene of a brutal fatal stabbing, Sunday, Oct. 27, 2013, in New York. Police say a mother and her four young children were killed in a late night stabbing rampage at a Sunset Park, Brooklyn, home. A Chinese immigrant, 25-year-old Ming Don Chen, was arrested Sunday on five counts of murder in the deaths of his cousin's wife and her four children. (AP Photo/Kathy Willens)
Women gather on the steps of an apartment building opposite the scene of a brutal fatal stabbing, Sunday, Oct. 27, 2013, in New York. Police say a mother and her four young children were killed in a late night stabbing rampage at a Sunset Park, Brooklyn, home. A Chinese immigrant, 25-year-old Ming Don Chen, was arrested Sunday on five counts of murder in the deaths of his cousin's wife and her four children. (AP Photo/Kathy Willens)
Crime scene detectives investigate the scene of a multiple fatal stabbing Sunday, Oct. 27, 2013, in New York. Police said a mother and her four young children were stabbed to death in a brutal rampage just before 11 p.m. Saturday in the Sunset Park neighborhood of Brooklyn. The New York Police Department said a suspect, 25-year-old Ming Don Chen, a Chinese immigrant, was arrested Sunday on five counts of murder in the deaths of his cousin's wife and her four children in the stabbing rampage in their Brooklyn home. (AP Photo/Kathy Willens)
A crime scene detective leaps up the steps at the scene of a multiple fatal stabbing Sunday, Oct. 27, 2013, in the Sunset Park neighborhood of Brooklyn, in New York. Police said a mother and her four young children were stabbed to death in a brutal rampage just before 11p.m. Saturday. The working-class neighborhood is home to many Chinese immigrants. (AP Photo/Kathy Willens)
Crime scene specialists work at the scene of a fatal stabbing, Sunday, Oct. 27, 2013, in the Brooklyn borough of New York. Police say a mother and her four young children were killed in a late night stabbing rampage at the Sunset Park, Brooklyn home, far right. (AP Photo/Kathy Willens)
Medical Examiner Transport personnel prepare to place a loaded body bag into their vehicle after exiting the residence of a crime scene in the Sunset Park neighborhood of Brooklyn Sunday, Oct. 27, 2013 where five people, including a toddler, were stabbed to death in New York. Emergency responders found three of the victims dead at the residence just before 11 p.m. Saturday. Two others were taken to Brooklyn hospitals, where they were pronounced dead. (AP Photo/John Minchillo)
NEW YORK (AP) — A Chinese immigrant was arrested Sunday on five counts of murder in the deaths of his cousin's wife and her four children in a stabbing rampage in their Brooklyn home.
The suspect, 25-year-old Ming Don Chen, implicated himself in the stabbings late Saturday in the Sunset Park neighborhood, police said. Chief of Department Phil Banks said the victims "were cut and butchered with a kitchen knife."
Two girls, 9-year-old Linda Zhuo and 7-year-old Amy Zhuo, were pronounced dead at the scene, along with the youngest child, 1-year-old William Zhuo. Their brother, 5-year-old Kevin Zhuo, and 37-year-old mother, Qiao Zhen Li, were taken to hospitals, where they also were pronounced dead.
Chen is a cousin of the children's father and had been staying at the home for the past week or so, Banks said. He came to the United States from China in 2004 and seemingly struggled to make it, Banks said.
"Ever since he came to this country, everybody seems to be doing better than him," he said.
On Saturday night, Chen had apparently been acting in such a way that concerned Li, Banks said. She tried to call her husband, who wasn't home, but couldn't reach him.
Banks said Li called her mother-in-law in China, who also was unsuccessful in reaching her son. The mother-in-law reached out to her daughter, who lives in the neighborhood, Banks said.
She and her husband came to the house and banged on the door, then called 911. Officers in the area investigating another matter responded, Banks said.
"It's a scene you'll never forget," he said. The victims had wounds in their necks and torsos.
Chen was in custody and wasn't immediately available to comment. He also faces counts of assault on a police officer, which happened while he was being processed, and resisting arrest, Banks said.
Bob Madden, who lives nearby, was out walking his dog when he saw a man being escorted from the building by police. He was barefoot, wearing jeans, and "he was staring, he was expressionless," Madden said.
Yuan Gao, a cousin of the mother, said the man had recently moved to the area and had been staying with different people.
Fire department spokesman Jim Long said emergency workers responded just before 11 p.m. to a 911 call from a person stabbed at the residence in Sunset Park, a working-class neighborhood of adjoining two-story brick buildings with a large Chinese community.
Neighbor May Chan told the Daily News it was "heartbreaking" to learn of the deaths.
"I always see (the kids) running around here," Chan said. "They run around by my garage playing. They run up and down screaming."
WASHINGTON (AP) — The Obama administration is appealing to its allies in Congress, on Wall Street and across the country to stick with President Barack Obama's health care law even as embarrassing problems with the flagship website continue to mount.
The website's troubled debut was overshadowed by the partial government shutdown that started the same day the website went live. Last week, Obama and Democrats walked away from a no-holds-barred fight with Republicans over debt and spending with a remarkable degree of unity, made all the more prominent by the deep GOP divisions the standoff revealed.
The debt-and-spending crisis averted for now, the spotlight has shifted to Obama's health care law and the web-based exchanges, beset by malfunctions, where Americans are supposed to be able to shop for insurance. The intensified focus has increased the pressure on Democrats to distance themselves from Obama's handling of the website's rollout as both parties demand to know what went wrong and why.
As the administration races to fix the website, it's deploying the president and top officials to urge his supporters not to give up.
"By now you have probably heard that the website has not worked as smoothly as it was supposed to," Obama said Tuesday in a video message recorded for Organizing for America, a nonprofit group whose mission is to support Obama's agenda. "But we've got people working overtime in a tech surge to boost capacity and address the problems. And we are going to get it fixed."
Whether through the website or other, lower-tech means, the administration needs millions of Americans to sign up through the exchanges for the law to succeed. While the website has become an easily maligned symbol of a law that Republicans despise, Obama said it's important Americans realize that "Obamacare," with its various patient protections, is much more.
"That's why I need your help," Obama told OFA's supporters.
The group has been organizing a multitude of events and social media campaigns around the health care law's implementation. OFA said those efforts will continue, but the group isn't adjusting its strategy in response to the website's issues.
Obama has turned to longtime adviser Jeffrey Zients to provide management advice to help fix the system. Zients, a former acting director of the Office of Management and Budget and a veteran management consultant, will be on a short-term assignment at the Health and Human Services Department before he's due to take over as director of Obama's National Economic Council next year.
Meanwhile, Vice President Joe Biden and top White House officials held a call with business leaders Tuesday about the health law and other issues. Business Forward, a trade group friendly to the White House, said the administration asked the group to invite leaders to hear directly from Biden.
In Congress, even staunch supporters of the law like House Democratic leader Nancy Pelosi and Rep. Steny Hoyer, the Democratic whip, have said the website's rollout was unacceptable. In a potentially worrying sign for Obama, Sen. Jeanne Shaheen, D-N.H., is calling for the White House to extend the open-enrollment period past March 31 in light of the glitches.
On Wednesday, the administration is sending Mike Hash, who runs the health reform office at HHS, to Capitol Hill to brief lawmakers on the law's implementation.
An invitation to the breakfast meeting obtained by The Associated Press says it's restricted to members of Congress. But only Democrats were invited to that session, prompting protest from House Speaker John Boehner, whose spokesman called it a "snub" and said the administration should brief House Republicans, too, in the name of transparency and accountability. Joanne Peters, a spokeswoman for HHS, said officials would be happy to honor additional briefing requests.
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Reach Josh Lederman at http://twitter.com/joshledermanAP
One of the coolest hacks we saw at the TechCrunch Europe hackathon today was built by two coders from Uruguay who have been hacking their way around the world for the last few months. Truly.am lets you verify who you are talking to online. Say somebody on Facebook or a dating site sends you a picture. How do you know they really are the person in that photo? Truly.am uses some cool HTML5 tools like WebRTC and the SkyBiometry facial recognition API to verify your conversation partners (or the people you meet on online dating sites) really look the way they say they do.
Here is how it works: somebody you don’t know sends you a picture. You then go to Truly.am, upload this picture and enter the person’s email address. That person then gets an email and has to verify his or her identity by using their webcam to take a series of images to train the recognition algorithm. Once those images are uploaded to the Truly.am servers, the facial recognition service takes over and checks them against the original image. Once the results come back, Truly.am tells the user if the image matched and the requester, of course, also gets an email with the results.
As Agustin Haller and Dayana Jabif, the two coders behind the project, told me, you often want to remain anonymous on the net, but in some cases, you really need to know at least a bit more information about the person you are talking to. This hack was partly inspired by their own experience with Airbnb, but I have no doubt that users on online dating sites will love this product. On those sites, after all, fake photos still reign supreme.
The team plans to expand this idea to include data from LinkedIn, Xing and other professional services as well, but for now, the facial recognition app is available here and you can give it a try to verify your own potential online dates now.
Truly.am Uses Facial Recognition To Help You Verify Your Online Dates
Georgian Dream ruling coalition's presidential candidate Georgy Margvelashvili, left, kisses his daughter Anna, outside a polling station during presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and a staunch U.S. ally. (AP Photo/Georgy Abdaladze)
Georgian Dream ruling coalition's presidential candidate Georgy Margvelashvili, left, kisses his daughter Anna, outside a polling station during presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and a staunch U.S. ally. (AP Photo/Georgy Abdaladze)
Georgian woman crouches as she leaves a voting booth during the presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and and a staunch U.S. ally. (AP Photo/Sergei Grits)
Georgian woman and her son cast a ballot at a polling station in the presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and a staunch U.S. ally. (AP Photo/Georgy Abdaladze)
Georgians cast their ballots in the presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and and a staunch U.S. ally. (AP Photo/Sergei Grits)
Georgians cast their ballots in the presidential election in Tbilisi, Georgia, Sunday, Oct. 27, 2013. Georgians are voting Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and and a staunch U.S. ally. (AP Photo/Sergei Grits)
TBILISI, Georgia (AP) — Georgians voted Sunday for a president to succeed Mikhail Saakashvili, who during nearly a decade in power has turned this former Soviet republic into a fledgling democracy and a staunch U.S. ally.
For Saakashvili, it's a bitter departure. The vote is expected to cement the control of his rival, billionaire Prime Minister Bidzina Ivanishvili, whose coalition routed Saakashvili's party in a parliamentary election a year ago.
Ivanishvili's chosen candidate, Giorgi Margvelashvili, a former university rector with little political experience, is expected to win Sunday's election. But much uncertainty remains.
Ivanishvili has promised to step down next month and nominate a new prime minister, who is almost certain to be approved by parliament. Under Georgia's new parliamentary system, the next prime minister will acquire many of the powers previously held by the president.
Ivanishvili has not yet named his choice to lead the country. And he says he intends to maintain influence over the government, although how is not entirely clear. But his fortune, estimated at $5.3 billion, gives him considerable leverage in this country of 4.5 million people with a gross domestic product of $16 billion.
Much uncertainty also hangs over Saakashvili's future. Since last year's election and what was in effect a transfer of power, dozens of people from Saakashvili's team, including several former government ministers, have been hit with criminal charges and some have been jailed, including the former prime minister.
Ivanishvili confirmed in an interview with The Associated Press that Saakashvili also is likely to be questioned by prosecutors once he leaves office next month.
Prosecutors have reopened a criminal inquiry into the 2005 death of Zurab Zhvania, who was Saakashvili's first prime minister. Zhvania's death was attributed to accidental carbon monoxide poisoning caused by a faulty gas heater, but his brother has accused Saakashvili of hiding the truth.
Saakashvili also may face questioning over the 2008 war with Russia, which ended with Russian troops in full control of two breakaway Georgian republics. His opponents accuse him of needlessly antagonizing Russia and giving Moscow a pretext to invade.
Saakashvili repeated Sunday that he has no plans to flee the country. "No one can forbid me either to leave the country or to stay, but I do not intend to leave Georgia," he told television journalists while jogging along the Black Sea coast in western Georgia.
His party needs its candidate, former parliamentary speaker David Bakradze, to finish a strong second among the 23 candidates to maintain political influence. Bakradze now leads the opposition faction in parliament.
Bakradze faces the biggest challenge from Nino Burdzhanadze, a veteran politician who boasts of good relations with Moscow and has called for Saakashvili to be jailed.
While Ivanishvili made his money in Russia and has had some success in restoring trade ties with Georgia's hostile neighbor, he has maintained the pro-Western course set by Saakashvili.
"Nobody can change this. This is the will of the Georgian people, to see their country in the EU and in NATO," said Alexi Petriashvili, one of Ivanishvili's ministers. "The majority see the U.S. as Georgia's strongest strategic partner."
If not for Washington, Georgia most likely wouldn't have survived as an independent state, Petriashvili told the AP. He pointed to Washington's support for the closing of Russian military bases in Georgia in 2005.
The U.S. supports Georgia diplomatically and financially, with assistance in 2013 totaling about $70 million.
Ivanishvili's government has come under pressure from U.S. and EU officials to show that the justice system isn't being used to settle political scores and to refrain from jailing Saakashvili.
Many Georgians became deeply disillusioned with what they saw as the excesses and authoritarian turn of the later years of Saakashvili's presidency.
The achievements of the early years, however, are difficult to deny. Saakashvili brought the economy out of the shadow, restored electricity supplies, eradicated a corrupt traffic police force, and laid the foundation for a democratic state.
Georgia's GDP has quadrupled since Saakashvili became president after leading the peaceful 2003 Rose Revolution.
"Yes, everyone forgot how we sat in the darkness and what kind of roads we had," Marina Vezirishvili, 46, said after voting in Tbilisi. "But just so you know, I'm not a member of Misha's party and I didn't vote for their candidate."
Saakashvili, commonly known as Misha, has earned wide international respect for allowing the government to change through the ballot box rather than through revolution for the first time in Georgia's post-Soviet history.
"We have to recognize, whatever our position is inside Georgian political fights, that Georgia has been a great example," said Joao Soares, head of an election monitoring mission from the Organization for Security and Co-operation in Europe.
Red Bull driver Sebastian Vettel of Germany waves to the crowd after winning the Indian Formula One Grand Prix and his 4th straight F1 world drivers championship at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. (AP Photo/Mark Baker)
Red Bull driver Sebastian Vettel of Germany waves to the crowd after winning the Indian Formula One Grand Prix and his 4th straight F1 world drivers championship at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. (AP Photo/Mark Baker)
Red Bull driver Sebastian Vettel of Germany throws his trophy in the air after winning the Indian Formula One Grand Prix and his 4th straight F1 world drivers championship at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. (AP Photo/Mark Baker)
Red Bull driver Sebastian Vettel of Germany celebrates on the track after winning the Indian Formula One Grand Prix and his 4th straight F1 world championship at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. (AP Photo/Mark Baker)
Red Bull driver Sebastian Vettel of Germany is held aloft by second placed Mercedes driver Nico Rosberg of Germany and third placed Lotus driver Romain Grosjean of France after winning the Indian Formula One Grand Prix and his 4th straight F1 world drivers championship at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. Red Bull's chief technical officer Adrian Newey , left. (AP Photo/Mark Baker)
Red Bull driver Mark Webber, right, of Australia is met by a teammate after his car stopped during the Indian Formula One Grand Prix at the Buddh International Circuit in Noida, India, Sunday, Oct. 27, 2013. (AP Photo/Mark Baker)
GREATER NOIDA, India (AP) — Red Bull's Sebastian Vettel claimed his fourth straight Formula One championship Sunday after turning in a trademark clinical performance to win the Indian Grand Prix.
Starting from pole, Vettel dominated the Buddh International Circuit to join F1 greats Juan Miguel Fangio and Michael Schumacher as just the third driver to win four consecutive championships. The only other driver to win four championships was Alain Prost.
"You've won it in style," an elated Red Bull team principal Christian Horner told Vettel over the car radio immediately after the race. "Brilliant stuff. You've joined the greats."
Vettel finished almost 30 seconds ahead of second placed Nico Rosberg in a Mercedes, with Lotus driver Romain Grosjean taking his second straight third place after starting from 17th on the grid.
After taking the checkered flag, Vettel performed several donuts on the track before climbing from his car, acknowledging the crowd and kneeling with his head bowed to the track. He then climbed the pit lane fence to embrace members of his team.
"I'm overwhelmed, don't know what to say," he said immediately after the race. "It is one of the best days of my life.
"I think back about where I started, when F1 was so far away. I have so many people to thank from go-carting to junior categories of F1," he added. "I always tried to listen, learn. It has been incredible to compete against the best, it is a very tough field, and come out on top of the world."
With Vettel's win, Red Bull has also claimed its fourth straight constructor's title, despite losing Mark Webber to mechanical problems while in second place.
Ferrari's Felipe Massa was fourth with teammate Fernando Alonso finishing a disappointing 11th.
Vettel, at 26 the youngest driver to win four world titles, has now won 10 races this season, including the last six. He has won all three Indian GP races from pole.
A clearly emotional Vettel, taking occasional swigs from his celebratory magnum of champagne, thanked his team, his family, spoke of his respect for the Indian people and rivals including Alonso, Lewis Hamilton and Webber in a post-race media conference.
"To win four titles, I don't know, it's just a big number you know? Four titles," he said. "Fangio put the number of five titles and everybody appreciated him as the best driver in the world. Michael (Schumacher) came along ... it's incredible that one guy managed to score more championships than (Fangio) did.
"I'm way too young to know what it means (to win four titles). ... It's difficult to realize something that nobody can take away from you basically."
Starting on the quick but fragile soft tires, Vettel lasted just one lap before switching to the medium compounds, emerging from the pit lane in 17th place.
With Webber in the lead, Vettel wove his way back toward the front, gradually narrowing the gap to the lead and passing second placed Perez on the 22nd lap to move into second.
Once Vettel overtook Perez, it was only a matter of time before Webber would be forced to change tires and relinquish the lead. Webber eventually entered the pits for his first tire change to soft tires on the 29th lap.
Vettel made his second and last stop on the 32nd lap to take on new medium tires, returning to the track just over eight seconds behind Webber.
Webber failed to make up enough time on the soft tires before switching back to mediums two laps later, effectively handing the race to Vettel.
"I'm not that old yet, I have goals, maybe in 10 years' time, I'll understand what we have done," Vettel said.
Red Bull ordered a stunned Webber to stop while in second place on the 42nd lap due to a problem with his car's alternator.
"Disappointing, but there's not much I can do," Webber said. "There was something wrong with the car, so we had to stop straight away."
With the Australian out, the race became a tussle for the lesser podium places, with pacesetting Rosberg passing Lotus driver Kimi Raikkonen for second on the closing laps.
Grosjean drove a dogged race to defy the odds and reach the podium after being eliminated in the first qualifying session Saturday.
"The car came back in the race, our strategy was good," he said. "It was tough, I'm very proud."
Curing HIV/AIDS gets tougher: Study shows far more 'hidden' and potentially active virus than once thought
PUBLIC RELEASE DATE:
24-Oct-2013
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Contact: David March dmarch1@jhmi.edu 410-955-1534 Johns Hopkins Medicine
Discovery of a larger than expected latent reservoir of HIV confounds 'shock and kill' cure strategy
Just when some scientists were becoming more hopeful about finding a strategy to outwit HIV's ability to resist, evade and otherwise survive efforts to rid it from the body, another hurdle has emerged to foil their plans, new research from Johns Hopkins shows.
In a cover-story report on the research to be published in the journal Cell online Oct. 24, Johns Hopkins infectious disease experts say the amount of potentially active, dormant forms of HIV hiding in infected immune T cells may actually be 60-fold greater than previously thought.
The hidden HIV, researchers say, is part of the so-called latent reservoir of functional proviruses that remains long after antiretroviral drug therapy has successfully brought viral replication to a standstill.
The disappointing finding comes after a three-year series of lab experiments, which they say represents the most detailed and comprehensive analysis to date of the latent reservoir of HIV proviruses. If antiretroviral therapy is stopped or interrupted, some proviruses can reactivate, allowing HIV to make copies of itself and resume infection of other immune cells.
Senior study investigator Robert Siliciano, M.D., Ph.D., who in 1995 first showed that reservoirs of dormant HIV were present in immune cells, says that while the latest study results show most proviruses in the latent reservoir are defective, curing the disease will depend on finding a way to target all proviruses with the potential to restart the infection.
Study results showed that among 213 HIV proviruses isolated from the reservoirs of eight patients and initially unresponsive to highly potent biological stimuli, some 12 percent could later still become active, and were capable of replicating their genetic material and transmitting infection to other cells. Siliciano says that all of these non-induced proviruses had previously been thought to be defective, with no possible role in resumption of the disease.
Siliciano, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator, says his team's latest study findings pose a serious problem to prevailing hopes for the so-called "shock and kill" approach to curing HIV.
That approach refers to forcing dormant proviruses to "turn back on," making them "visible" and vulnerable to the immune system's cytolytic "killer" T cells, and then eliminating every last infected cell from the body while antiretroviral drugs prevent any new cells from becoming infected.
Siliciano says this new discovery could boost support for alternative approaches to a cure, including renewed efforts to develop a therapeutic vaccine to stimulate immune system cells that attack and kill all HIV. "Our study results certainly show that finding a cure for HIV disease is going to be much harder than we had thought and hoped for," he says.
Lead study investigator and Johns Hopkins postdoctoral fellow Ya-Chi Ho, M.D., Ph.D., says the team's investigation of "the true size" of the latent reservoir was prompted by a large discrepancy between the two established techniques for measuring how much provirus is in immune system cells. She says the team's original method of calculating only reactivated proviruses yielded numbers that were 300-fold lower than a DNA-based technique used to gauge how many total proviral copies, both dormant and reactivated, are present. "If medical researchers are ever going to lure out and reactivate latent HIV, then we need to better understand exactly how much of it is really there," says Ho.
In the latest study, researchers sequenced, or spelled out, the entire genetic code of HIV proviruses that reactivated and those that could not be induced to do so. Twenty-five of the 213 non-induced isolates, when sequenced, had fully intact genomes when compared to those that did reactivate. Analysis of the remaining (88 percent of) non-induced proviruses showed that all were defective, possessing genetic deletions and mutations that would forestall viral replication.
Further lab experiments on the cloned proviruses showed that the intact, non-induced proviruses could be reconstructed to produce active virus, which in turn could replicate in human immune cells. Researchers also found that cloned proviral DNA lacked a latency-inducing chemical methyl group.
When researchers looked at where non-induced proviral DNA showed up in infected human immune cells, they found some 92 percent of the non-induced proviral DNA was located in actively transcribed regions of the human cell DNA. This finding, they say, suggests that non-induced proviral DNA is not permanently hidden in some inaccessible regions of the host chromosomes but instead lies in regions where it could become reactivated.
Statistical modeling later showed these figures equated to a 60-fold increase in the potential size of the latent reservoir when compared to the team's original method for counting only reactivated viruses.
Additional experiments showed that repeated chemical stimuli could reactivate proviruses that failed to respond to initial attempts at reactivation.
Ho says the study results, although discouraging, will energize HIV experts to refine and improve methods for detecting proviruses capable of reactivation.
Siliciano is next helping to organize in November a San Francisco conference, jointly sponsored by the journals Cell and The Lancet, entitled "What Will it Take to Achieve an AIDS-free World?"
###
Funding support for this research was provided by the amfAR Research Collaboration on HIV Eradication, and the Martin Delaney CARE and DARE Collaboraties of the National Institutes of Health and the National Institute of Allergy and Infectious Diseases, the Johns Hopkins Center for AIDS Research, and the Howard Hughes Medical Institute. Corresponding federal grant numbers are AI096113, 1U19AI096109 and AI043222.
Besides Siliciano and Ho, other researchers involved in this study, performed entirely at Johns Hopkins, were Liang Shan, Ph.D.; Nina Hosmane, B.A.; Jeffrey Wang, B.A.; Sarah Laskey, B.A.; Daniel Rosenbloom, Ph.D.; Jun Lai, B.A.; Joel Blankson, M.D., Ph.D.; and Janet Siliciano, Ph.D.
Currently, there are more than 34 million people in the world living with HIV, including an estimated 1,178,000 in the United States and 23,000 in the state of Maryland.
Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's vision, "Together, we will deliver the promise of medicine," is supported by its mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, and more than 30 primary health care outpatient sites. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years in a row by U.S. News & World Report.
JHM
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Curing HIV/AIDS gets tougher: Study shows far more 'hidden' and potentially active virus than once thought
PUBLIC RELEASE DATE:
24-Oct-2013
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Contact: David March dmarch1@jhmi.edu 410-955-1534 Johns Hopkins Medicine
Discovery of a larger than expected latent reservoir of HIV confounds 'shock and kill' cure strategy
Just when some scientists were becoming more hopeful about finding a strategy to outwit HIV's ability to resist, evade and otherwise survive efforts to rid it from the body, another hurdle has emerged to foil their plans, new research from Johns Hopkins shows.
In a cover-story report on the research to be published in the journal Cell online Oct. 24, Johns Hopkins infectious disease experts say the amount of potentially active, dormant forms of HIV hiding in infected immune T cells may actually be 60-fold greater than previously thought.
The hidden HIV, researchers say, is part of the so-called latent reservoir of functional proviruses that remains long after antiretroviral drug therapy has successfully brought viral replication to a standstill.
The disappointing finding comes after a three-year series of lab experiments, which they say represents the most detailed and comprehensive analysis to date of the latent reservoir of HIV proviruses. If antiretroviral therapy is stopped or interrupted, some proviruses can reactivate, allowing HIV to make copies of itself and resume infection of other immune cells.
Senior study investigator Robert Siliciano, M.D., Ph.D., who in 1995 first showed that reservoirs of dormant HIV were present in immune cells, says that while the latest study results show most proviruses in the latent reservoir are defective, curing the disease will depend on finding a way to target all proviruses with the potential to restart the infection.
Study results showed that among 213 HIV proviruses isolated from the reservoirs of eight patients and initially unresponsive to highly potent biological stimuli, some 12 percent could later still become active, and were capable of replicating their genetic material and transmitting infection to other cells. Siliciano says that all of these non-induced proviruses had previously been thought to be defective, with no possible role in resumption of the disease.
Siliciano, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator, says his team's latest study findings pose a serious problem to prevailing hopes for the so-called "shock and kill" approach to curing HIV.
That approach refers to forcing dormant proviruses to "turn back on," making them "visible" and vulnerable to the immune system's cytolytic "killer" T cells, and then eliminating every last infected cell from the body while antiretroviral drugs prevent any new cells from becoming infected.
Siliciano says this new discovery could boost support for alternative approaches to a cure, including renewed efforts to develop a therapeutic vaccine to stimulate immune system cells that attack and kill all HIV. "Our study results certainly show that finding a cure for HIV disease is going to be much harder than we had thought and hoped for," he says.
Lead study investigator and Johns Hopkins postdoctoral fellow Ya-Chi Ho, M.D., Ph.D., says the team's investigation of "the true size" of the latent reservoir was prompted by a large discrepancy between the two established techniques for measuring how much provirus is in immune system cells. She says the team's original method of calculating only reactivated proviruses yielded numbers that were 300-fold lower than a DNA-based technique used to gauge how many total proviral copies, both dormant and reactivated, are present. "If medical researchers are ever going to lure out and reactivate latent HIV, then we need to better understand exactly how much of it is really there," says Ho.
In the latest study, researchers sequenced, or spelled out, the entire genetic code of HIV proviruses that reactivated and those that could not be induced to do so. Twenty-five of the 213 non-induced isolates, when sequenced, had fully intact genomes when compared to those that did reactivate. Analysis of the remaining (88 percent of) non-induced proviruses showed that all were defective, possessing genetic deletions and mutations that would forestall viral replication.
Further lab experiments on the cloned proviruses showed that the intact, non-induced proviruses could be reconstructed to produce active virus, which in turn could replicate in human immune cells. Researchers also found that cloned proviral DNA lacked a latency-inducing chemical methyl group.
When researchers looked at where non-induced proviral DNA showed up in infected human immune cells, they found some 92 percent of the non-induced proviral DNA was located in actively transcribed regions of the human cell DNA. This finding, they say, suggests that non-induced proviral DNA is not permanently hidden in some inaccessible regions of the host chromosomes but instead lies in regions where it could become reactivated.
Statistical modeling later showed these figures equated to a 60-fold increase in the potential size of the latent reservoir when compared to the team's original method for counting only reactivated viruses.
Additional experiments showed that repeated chemical stimuli could reactivate proviruses that failed to respond to initial attempts at reactivation.
Ho says the study results, although discouraging, will energize HIV experts to refine and improve methods for detecting proviruses capable of reactivation.
Siliciano is next helping to organize in November a San Francisco conference, jointly sponsored by the journals Cell and The Lancet, entitled "What Will it Take to Achieve an AIDS-free World?"
###
Funding support for this research was provided by the amfAR Research Collaboration on HIV Eradication, and the Martin Delaney CARE and DARE Collaboraties of the National Institutes of Health and the National Institute of Allergy and Infectious Diseases, the Johns Hopkins Center for AIDS Research, and the Howard Hughes Medical Institute. Corresponding federal grant numbers are AI096113, 1U19AI096109 and AI043222.
Besides Siliciano and Ho, other researchers involved in this study, performed entirely at Johns Hopkins, were Liang Shan, Ph.D.; Nina Hosmane, B.A.; Jeffrey Wang, B.A.; Sarah Laskey, B.A.; Daniel Rosenbloom, Ph.D.; Jun Lai, B.A.; Joel Blankson, M.D., Ph.D.; and Janet Siliciano, Ph.D.
Currently, there are more than 34 million people in the world living with HIV, including an estimated 1,178,000 in the United States and 23,000 in the state of Maryland.
Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is a $6.7 billion integrated global health enterprise and one of the leading health care systems in the United States. JHM unites physicians and scientists of the Johns Hopkins University School of Medicine with the organizations, health professionals and facilities of The Johns Hopkins Hospital and Health System. JHM's vision, "Together, we will deliver the promise of medicine," is supported by its mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care. Diverse and inclusive, JHM educates medical students, scientists, health care professionals and the public; conducts biomedical research; and provides patient-centered medicine to prevent, diagnose and treat human illness. JHM operates six academic and community hospitals, four suburban health care and surgery centers, and more than 30 primary health care outpatient sites. The Johns Hopkins Hospital, opened in 1889, was ranked number one in the nation for 21 years in a row by U.S. News & World Report.
JHM
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Contact: Rob Gutro robert.j.gutro@nasa.gov NASA/Goddard Space Flight Center
NASA's TRMM satellite flew above the center of Tropical Storm Francisco in the western North Pacific Ocean early on Oct. 24 and data was used to create a 3-D image of the storm's structure.
Tropical Storm Francisco came into the view of the Tropical Rainfall Measuring Mission or TRMM satellite at 0919 UTC/5:19 a.m. EDT. Francisco is somewhat close to Super-typhoon Lekima, also in the northwestern Pacific Ocean. Lekima was located southeast of Tropical Storm Francisco over the open waters of the Pacific.
At NASA's Goddard Space Flight Center in Greenbelt, Md. the data TRMM gathered was used to create imagery of the storm. Precipitation data from TRMM's Microwave Imager (TMI) and Precipitation Radar (PR) instruments were overlaid on infrared images from TRMM's Visible and InfraRed Scanner (VIRS).
TRMM data showed a difference between Lekima and Francisco. TRMM's PR data revealed that Lekima had a small well defined eye at the center of the super typhoon with another concentric outer replacement eye wall. Rain was falling at a rate of over 130mm/~5.2 inches per hour in the powerful storms in Lekima's outer eye wall. Francisco was also a super typhoon on Oct. 20, 2013 but had greatly weakened by the time of the latest TRMM pass. Francisco now had a very large area in the center of the storm that was rain free. Lekima was the fourth super typhoon in the western Pacific this year with wind speeds estimated to be over 130 knots/~150 mph.
Radar reflectivity data from TRMM's PR instrument were used to create 3-D images that showed differences between super typhoon Lekima and tropical storm Francisco. TRMM is managed by both NASA and the Japan Aerospace Exploration Agency.
On Oct. 24 at 1500 UTC/11 a.m. EDT, Francisco's maximum sustained winds were near 60 knots/69 mph/111 kph. Francisco was centered near 26.9 north and 130.8 east, about 134 nautical miles east of Kadena Air Base, Okinawa, Japan. Francisco was moving to the northeast at 7 knots/8 mph/12.9 kph and away from the island.
Francisco is being pushed to the northeast by mid-latitude westerly winds, which are also affect Super-typhoon Lekima behind it. The tropical storm appears elongated on satellite imagery today showing the effect that the westerlies are having on it. Francisco is expected to continue on a northeast track paralleling eastern Japan, but staying out to sea.
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NASA sees rainfall in Tropical Storm Francisco
PUBLIC RELEASE DATE:
24-Oct-2013
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Contact: Rob Gutro robert.j.gutro@nasa.gov NASA/Goddard Space Flight Center
NASA's TRMM satellite flew above the center of Tropical Storm Francisco in the western North Pacific Ocean early on Oct. 24 and data was used to create a 3-D image of the storm's structure.
Tropical Storm Francisco came into the view of the Tropical Rainfall Measuring Mission or TRMM satellite at 0919 UTC/5:19 a.m. EDT. Francisco is somewhat close to Super-typhoon Lekima, also in the northwestern Pacific Ocean. Lekima was located southeast of Tropical Storm Francisco over the open waters of the Pacific.
At NASA's Goddard Space Flight Center in Greenbelt, Md. the data TRMM gathered was used to create imagery of the storm. Precipitation data from TRMM's Microwave Imager (TMI) and Precipitation Radar (PR) instruments were overlaid on infrared images from TRMM's Visible and InfraRed Scanner (VIRS).
TRMM data showed a difference between Lekima and Francisco. TRMM's PR data revealed that Lekima had a small well defined eye at the center of the super typhoon with another concentric outer replacement eye wall. Rain was falling at a rate of over 130mm/~5.2 inches per hour in the powerful storms in Lekima's outer eye wall. Francisco was also a super typhoon on Oct. 20, 2013 but had greatly weakened by the time of the latest TRMM pass. Francisco now had a very large area in the center of the storm that was rain free. Lekima was the fourth super typhoon in the western Pacific this year with wind speeds estimated to be over 130 knots/~150 mph.
Radar reflectivity data from TRMM's PR instrument were used to create 3-D images that showed differences between super typhoon Lekima and tropical storm Francisco. TRMM is managed by both NASA and the Japan Aerospace Exploration Agency.
On Oct. 24 at 1500 UTC/11 a.m. EDT, Francisco's maximum sustained winds were near 60 knots/69 mph/111 kph. Francisco was centered near 26.9 north and 130.8 east, about 134 nautical miles east of Kadena Air Base, Okinawa, Japan. Francisco was moving to the northeast at 7 knots/8 mph/12.9 kph and away from the island.
Francisco is being pushed to the northeast by mid-latitude westerly winds, which are also affect Super-typhoon Lekima behind it. The tropical storm appears elongated on satellite imagery today showing the effect that the westerlies are having on it. Francisco is expected to continue on a northeast track paralleling eastern Japan, but staying out to sea.
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St. Louis Cardinals' Allen Craig gets tangled with Boston Red Sox's Will Middlebrooks during the ninth inning of Game 3 of baseball's World Series Saturday, Oct. 26, 2013, in St. Louis. Middlebrooks was called for obstruction on the play and Craig went in to score the game-winning run. The Cardinals won 5-4 to take a 2-1 lead in the series. (AP Photo/David J. Phillip)
St. Louis Cardinals' Allen Craig gets tangled with Boston Red Sox's Will Middlebrooks during the ninth inning of Game 3 of baseball's World Series Saturday, Oct. 26, 2013, in St. Louis. Middlebrooks was called for obstruction on the play and Craig went in to score the game-winning run. The Cardinals won 5-4 to take a 2-1 lead in the series. (AP Photo/David J. Phillip)
St. Louis Cardinals' Allen Craig gets tangled with Boston Red Sox's Will Middlebrooks during the ninth inning of Game 3 of baseball's World Series Saturday, Oct. 26, 2013, in St. Louis. Middlebrooks was called for obstruction on the play and Craig went in to score the game-winning run. The Cardinals won 5-4 to take a 2-1 lead in the series. (AP Photo/David J. Phillip)
Boston Red Sox catcher Jarrod Saltalamacchia watches as home plate umpire Dana DeMuth calls St. Louis Cardinals' Allen Craig safe on an obstruction during the ninth inning of Game 3 of baseball's World Series Saturday, Oct. 26, 2013, in St. Louis. The Cardinals won 5-4 to take a 2-1 lead in the series. (AP Photo/David J. Phillip)
Teammates mob St. Louis Cardinals' Allen Craig at home after Craig scored the game-winning run on an obstruction call during the ninth inning of Game 3 of baseball's World Series against the Boston Red Sox Saturday, Oct. 26, 2013, in St. Louis. (AP Photo/Charlie Riedel)
St. Louis Cardinals' Yadier Molina reacts as Allen Craig lays on home plate after getting tangled with Boston Red Sox's Will Middlebrooks during the ninth inning of Game 3 of baseball's World Series Saturday, Oct. 26, 2013, in St. Louis. Middlebrooks was called for obstruction on the play and Craig went in to score the game-winning run. The Cardinals won 5-4 to take a 2-1 lead in the series.(AP Photo/Charlie Riedel)
ST. LOUIS (AP) — The Cardinals rushed to the plate to congratulate Allen Craig. The Red Sox stormed home to argue with the umpires.
The fans, well, they seemed too startled to know what to do. Who'd ever seen an obstruction call to end a World Series game?
No one.
In perhaps the wildest finish imaginable, the rare ruling against third baseman Will Middlebrooks allowed Craig to score with two outs in the bottom of the ninth inning and lifted St. Louis over Boston 5-4 Saturday night for a 2-1 edge.
A walk-off win? More like a trip-off.
"I'm in shock right now," St. Louis catcher Yadier Molina said.
So was most everyone at Busch Stadium after the mad-cap play.
"Tough way to have a game end, particularly of this significance," Red Sox manager John Farrell said.
After an umpire's call was the crux of Game 1 and a poor Boston throw to third base decided Game 2, the key play on this night combined both elements.
Molina singled with one out in the ninth off losing pitcher Brandon Workman. Craig, just back from a sprained foot, pinch-hit and lined Koji Uehara's first pitch into left field for a double that put runners on second and third.
With the infield in, Jon Jay hit a grounder to diving second baseman Dustin Pedroia. He made a sensational stab and threw home to catcher Jarrod Saltalamacchia, who tagged out the sliding Molina.
But then Saltalamacchia threw wide of third trying to get Craig. The ball glanced off Middlebrooks' glove and Craig's body, caroming into foul territory down the line.
After the ball got by, Middlebrooks, lying on his stomach, raised both legs and tripped Craig, slowing him down as he tried to take off for home.
"I just know I have to dive for that ball. I'm on the ground. There's nowhere for me to go," Middlebrooks said.
Third base umpire Jim Joyce immediately signaled obstruction.
"With the defensive player on the ground, without intent or intent, it's still obstruction," Joyce said. "You'd probably have to ask Middlebrooks that one, if he could have done anything. But that's not in our determination."
Craig kept scrambling.
"He was in my way. I couldn't tell you if he tried to trip me or not. I was just trying to get over him," he said.
Left fielder Daniel Nava retrieved the ball and made a strong throw home, where Saltalamacchia tagged a sliding Craig in time. But plate umpire Dana DeMuth signaled safe and then pointed to third, making clear the obstruction had been called.
"I was excited at first because we nailed the guy at home. I wasn't sure why he was called safe," Middlebrooks said.
"We're all running to home to see why he was called safe. We didn't think there was any obstruction there, obviously. As I'm getting up, he trips over me. I don't know what else to say."
Said Cardinals slugger Matt Holliday: "You hate for it to end on a somewhat controversial play."
"You would like for it to end a little cleaner, but that's part of it," he said.
Joyce and crew chief John Hirschbeck said they'd never seen a similar game-ending play.
A neat coincidence, though: In 2004, umpire Paul Emmel called obstruction on Seattle shortstop Jose Lopez, ruling he blocked Carl Crawford's sightline and giving Tampa Bay the game-ending run. Emmel was the first base umpire on this night, too.
The umpires all agreed Joyce got it right. Until now, he was best known for making an admittedly wrong call in 2010 that denied Detroit's Armando Galarraga a perfect game.
Game 4 is Sunday night, with Clay Buchholz starting for Boston against Lance Lynn.
To some Cardinals fans, the call meant long overdue payback. They're still smarting from Don Denkinger's missed call that helped cost them the 1985 World Series.
To some Red Sox fans, the tangle might've brought back painful memories from the 1975 World Series. In Game 3, Cincinnati's Ed Armbrister wasn't called for interference by plate umpire Larry Barnett when he blocked Boston catcher Carlton Fisk on a 10th-inning bunt. Fisk made a wild throw, setting up Joe Morgan's winning single.
Craig returned for this Series from a sprained left foot that had sidelined him since early September. After an awkward slide on the final play, he hobbled off the field in apparent discomfort.
The Red Sox scored twice in the eighth to tie it 4-all. Jacoby Ellsbury led off with a single and Shane Victorino was hit by a pitch for the sixth time this postseason. Both runners moved up on Pedroia's groundout, and David Ortiz was intentionally walked.
Cardinals manager Mike Matheny went to hard-throwing closer Trevor Rosenthal with the bases loaded, hoping for a five-out save from a rookie who has looked almost untouchable this October. But the Red Sox pushed two runs across.
Nava drove in one with a short-hop grounder that was smothered by second baseman Kolten Wong, who had just entered on defense in a double-switch.
Wong went to second for the forceout, but Nava beat the relay and Ellsbury scored to make it 4-3. Xander Bogaerts tied it when he chopped a single up the middle.
Workman jammed Holliday and retired the slugger on a routine fly with two on to end the bottom of the eighth. That sent the game to the ninth tied at 4. Rosenthal wound up with the win.
Holliday's two-run double put the Cardinals on top 4-2 in the seventh.
It was a tough inning for Red Sox reliever Craig Breslow. Matt Carpenter reached safely when he checked his swing on an infield single to shortstop. Carlos Beltran was grazed on the elbow pad by a pitch — making no effort to get out of the way.
Beltran, in fact, almost appeared to stick his elbow out just a tiny bit to make sure the ball made contact.
Junichi Tazawa came on and Holliday pulled a grounder past Middlebrooks at third. The ball kicked into the left-field corner and Holliday went all the way to third on the throw to the plate.
Tazawa then got a couple of strikeouts and prevented further damage.
It was Middlebrooks' first inning in the field. He entered as a pinch-hitter in the top of the seventh and took over at third base in the bottom half.
That shifted Bogaerts to shortstop — and neither one was able to make the difficult defensive play Boston needed in that inning.
Cardinals starter Joe Kelly, one of the few major league pitchers to wear glasses on the mound, set down his first nine batters. The Red Sox seemed to see him better the next time around in coming back from a 2-0 deficit.
Bogaerts opened the fifth with a triple that banged-up right fielder Beltran couldn't quite reach. The rookie later scored on a grounder by pinch-hitter Mike Carp.
Slumping Shane Victorino drew a leadoff walk from Kelly in the sixth and wound up scoring the tying run. Ortiz grounded a single off lefty reliever Randy Choate, and Nava greeted Seth Maness with an RBI single that made it 2-all.
Their fielding woes from Game 1 far behind them, the slick-fielding Cardinals made several sharp plays. Kelly barehanded a one-hopper, Carpenter threw out a runner from his knees up the middle and third baseman David Freese backhanded a line drive.
St. Louis quickly broke ahead, scoring in the first inning for the first time this October on RBI singles by Holliday and Molina. After the Cardinals got three hits in a span of four pitches, Red Sox reliever Felix Doubront began heating up in a hurry before Jake Peavy settled down.
NOTES: With no DH, Red Sox slugger Mike Napoli was on the bench. Workman batted in the ninth and struck out; Farrell said he needed another inning from the reliever. ... Cardinals Hall of Famers Bob Gibson, Lou Brock, Ozzie Smith and Red Schoendienst took part in the first-ball festivities, with fan favorite Willie McGee tossing the pitch. ... At 21, Bogaerts became the third-youngest player to hit a triple in a World Series. Ty Cobb and Mickey Mantle did it at 20. ... Molina has a six-game hitting streak in World Series play. ... The family of late umpire Wally Bell was in the stands. Bell died at 48 this month, and the six-man crew is wearing patches to honor him. Bell's first plate job in the World Series was at this ballpark in 2006.
ST. LOUIS (AP) — A look at Game 3 of the World Series at Busch Stadium on Saturday night as the Boston Red Sox take on the St. Louis Cardinals:
___
ONE-RUN GAME: A leadoff triple by rookie Xander Bogaerts helps Boston trim the deficit to 2-1 in the fifth inning.
Right fielder Carlos Beltran, playing with those bruised ribs, couldn't cut off the ball in the gap. Beltran was unable to bend over enough to glove the ball — or perhaps he had an idea how much it would hurt and shied away.
Stephen Drew followed with a strikeout, but Bogaerts scored when pinch-hitter Mike Carp bounced a chopper to second base. St. Louis got the force at second, but Carp easily beat the relay to first as Bogaerts scored.
Joe Kelly struck out Jacoby Ellsbury to end the inning.
With all the talk about the Boston beards, nobody ever seems to mention Carp's bright red number. Yes, he's a bench player — but it's an epic effort.
Long, straight, stiff as a board. Definitely has an Amish look to it. Or maybe more Scandinavian. Tough to choose.
Carp batted for pitcher Jake Peavy, so left-hander Felix Doubront is on in the bottom of the fifth.
Doubront retires David Freese with two on to end the inning. Cardinals lead 2-1.
___
ESCAPE: Peavy pitches out of major trouble in the fourth inning. Bases loaded, nobody out — Cardinals don't score.
Conservative move by third base coach Jose Oquendo to hold Yadier Molina at third on Jon Jay's single to center. Looked as though it would have been tough to throw out Molina at the plate. And with light-hitting Pete Kozma and pitcher Joe Kelly up next, probably a good time to take that chance.
Molina, however, wasn't running very well as he got to third, and Oquendo threw up a late stop sign.
Kozma was called out on strikes before Kelly and Matt Carpenter popped up.
Good move by Cardinals manager Mike Matheny to let Jay swing the bat instead of bunt with runners at first and second and none out. Again, with the bottom of the lineup to follow, good time to be aggressive.
Matheny certainly was. Oquendo was not.
___
SETTLING IN: Peavy looked much sharper in the second and third than he did in the first inning. Maybe he's settling down a bit and finding his rhythm.
Peavy is a fiery guy on the mound, often yelling at himself in the middle of a game. Controlling his emotions can be an issue for him. Perhaps Peavy was a little over-amped in the first inning.
Cardinals still lead 2-0 after Joe Kelly strikes out Daniel Nava on a full-count pitch with two on to end the top of the fourth.
Jacoby Ellsbury's leadoff grounder in the fourth got past a diving Matt Carpenter at second base for Boston's first hit.
___
SLOPPY PLAY: Ellsbury and the Red Sox catch a break on some bad baserunning by Matt Holliday in the third.
Playing deep against Holliday, Ellsbury ran in a long way on a popup to shallow center and appeared to have some trouble with the wind. Ellsbury dropped the ball for an error, but second baseman Dustin Pedroia alertly fired to first to throw out Holliday, who rounded the bag too far and was slow trying to get back.
Probably should have reached second safely if he had busted it out of the box the whole way.
These teams tied for the best regular-season record in the majors, but there certainly has been some sloppy play so far in this Series.
___
EARLY LEAD: Run-scoring singles by Holliday and Yadier Molina give St. Louis a 2-0 lead in the first inning.
The Cardinals are 7-0 when scoring first this postseason. That flame-throwing young bullpen has a lot to do with that. You don't want to be behind in the late innings against this team.
Peavy, coming off a poor start in the ALCS against Detroit, doesn't appear to have many answers so far tonight, either. Several hard-hit line drives so far, though the Cardinals do not have an extra-base hit yet.
Interesting play by Carlos Beltran after Matt Carpenter's leadoff single. When the count went to 3-1 and Boston third baseman Xander Bogaerts shifted further off the line, Beltran tried to bunt for a base hit. He was thrown out by Peavy and credited with a sacrifice.
Beltran's bruised ribs might have had something to do with that decision. Fox sideline reporter Ken Rosenthal had just noted that Beltran took another pain-killing injection before the game but said he was feeling better.
Rosenthal, however, said Beltran told him he feels more comfortable swinging right-handed than left-handed since banging into the outfield wall in Game 1. Beltran feels as though his bat is dragging from the left side, Rosenthal said.
___
HERE WE GO: Under way in Game 3 as the World Series shifts to Busch Stadium in St. Louis.
Peavy was 0-1 with an 8.31 ERA in two playoff starts this month, though he did pitch well for 5 2-3 innings against Tampa Bay in the division series. This will be the first career World Series start for the 2007 NL Cy Young Award winner.
Joe Kelly gets the ball for the Cardinals. He was 0-1 with a 4.41 ERA in three playoff starts.
Wearing those distinctive goggles, Kelly looks fired-up. Pumping in a heater at 98 mph in the first inning, he struck out Jacoby Ellsbury looking and then grabbed a comebacker barehanded.
Carpenter helped Kelly with a spectacular, diving play in the second to rob Daniel Nava of a hit. Nava getting his first World Series start in left field instead of Jonny Gomes.
Fox notes that 16 of the past 18 World Series that were tied 1-all were won by the team that took Game 3.
___
UNFAMILIAR TERRITORY: With the move to the NL ballpark, there was no designated hitter allowed. Wanting to keep David Ortiz in the lineup after he homered in Games 1 and 2, Red Sox manager John Farrell put Big Papi at first base — where he played just 39 innings during the regular season.
Mike Napoli relegated to the bench for Boston, taking a big bat out of the lineup.
___
HELP, PLEASE: In the first two games of the Series, Ortiz and Dustin Pedroia combined for seven hits in 13 at-bats. The rest of the Red Sox were 5 for 51 for an .098 batting average.
___
EQUINE GUESTS: The Budweiser Clydesdales took a lap around the warning track before player introductions. Anheuser-Busch Cos. Inc. owned the Cardinals from 1953-96.
There also was a pregame video tribute to Hall of Famer Stan Musial, the Cardinals great who died in January.
Willie McGee, the former St. Louis outfielder and 1985 NL MVP, threw out the first ball.
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